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Pharmacy and Pharmaceutical Sciences Research

Research identifies critical protein in cancer treatment-related heart damage

By Judith Van Dongen, WSU Spokane Office of Research

SPOKANE, Wash. – Many cancers can be successfully treated, but treatment itself often comes with risks as well. Cancer therapy that uses anthracyclines—a class of commonly used chemotherapy drugs—has been associated with heart damage that can eventually result in heart failure. It is thought to be the reason why heart disease is a leading cause of death in cancer survivors, immediately following cancer recurrence.

Scientists have not fully understood how exposure to anthracyclines can lead to heart failure, but a new study led by researchers at Washington State University has made a giant leap toward … » More …

What role does sleep play in sun damage and skin repair?

In 2010, the International Agency for Research on Cancer under the World Health Organization recognized night shift work that disrupts the circadian rhythm as “probably carcinogenic to humans.” This official recognition of the link between cancer and sleep disruption was a defining moment for Dr. Shobhan Gaddameedhi, an assistant professor in the Department of Pharmaceutical Sciences. » More ...

Study Suggests Biological Clock is Key to Reducing Heart Damage from Radiation Therapy

By Judith Van Dongen, WSU Health Sciences Spokane Office of Research

SPOKANE, Wash. – Treatment for breast cancer commonly includes radiation therapy, which offers good chances of success but comes with a serious long-term side effect: toxicity due to radiation that reaches the heart, causing DNA damage in healthy heart cells. Over time, this can lead to heart disease and eventually heart failure.

A new study conducted by researchers in the Washington State University College of Pharmacy and Pharmaceutical Sciences suggests that a preventive solution may lie in the biological clock, the built-in time-keeping mechanism that keeps us on a 24-hour cycle of rest … » More …

Finding the right dosing for children

Prescribe at your own risk. That is the general feeling that most doctors get when prescribing medicine to children. Due to ethical and legal challenges, conducting clinical trials on children has proven to be a major obstacle for drug researchers. In fact, many prescription drugs rarely go through clinical trials using children. As a result, doctors only have two options in pediatric care: 1. Don’t prescribe children drugs shown to be effective in adults, or 2. Prescribe drugs off-label to children at their own risk. That’s where Dr. Bhagwat Prasad, Associate Professor in Pharmaceutical Sciences at WSU, is transforming pediatric precision medicine so that drugs … » More …

New technology promises improved treatment of inflammatory diseases

By Judith Van Dongen, Office of Research, WSU Health Sciences Spokane

SPOKANE, Wash. – A study led by researchers at Washington State University has uncovered a potential new treatment approach for diseases associated with inflammation, including sepsis, stroke, rheumatoid arthritis, acute lung injury, and atherosclerosis.

Published in the open-access journal Science Advances, their paper describes a novel, patent-pending technology that uses nanosized particles to transport cell-killing drugs directly to activated neutrophils, the cells that drive the exaggerated immune response involved in inflammatory diseases. They also demonstrated the technology’s feasibility at selectively killing activated neutrophils without harming other cell types or compromising the immune system.

… » More …

WSU study identifies new target for treatment of gout

Pharmaceutical Sciences researchers have identified a new therapeutic target for the treatment of gout, a common type of arthritis that causes episodes of painful and stiff joints. The research lays the foundation for the development of potential new treatment strategies that could significantly improve the quality of life of millions of people around the world who suffer from the condition. » More ...

Pharmacy’s TIPed Institute focuses on changes to healthcare and education

Original post by Addy Hatch, WSU News

Big changes are coming to healthcare.

That was the message behind three days of speakers and workshops at the TIPed Institute on the Washington State University Health Sciences campus.

The institute is sponsored by the WSU College of Pharmacy and Pharmaceutical Sciences; TIPed means Transformation and Innovation in Pharmacy Education. But many of the technologies and teaching methods discussed will affect all aspects of healthcare.

For example, Steve Riddle, director of clinical development for Pharmacy OneSource/Wolters Kluwer, said the complexity and cost of the current healthcare system, as well as its failure to … » More …

WSU discovery could aid in battle of debilitative and deadly inflammation

By Charlie Powell, College of Veterinary Medicine

PULLMAN, Wash.—Most, if not all, infections and diseases in animals and people are met with some level of the body’s own inflammatory response.  Sometimes this inflammatory response crosses a line from being protective and useful to becoming debilitative or even deadly.

Scientists in Washington State University’s College of Veterinary Medicine and College of Pharmacy and Pharmaceuticals Sciences (CPPS) have discovered an important step in the progression of the body’s inflammatory response that may soon lead to effective management and treatments. The team’s paper was published Monday in the prestigious journal, Nature Communications.

“Inflammation is vital for life, without it … » More …

Worldwide rare disease study led by WSU researchers

By Judith Van Dongen, WSU Spokane Office of Research

Scientists at Washington State University are leading a new study that will take them one step closer to making treatment options available to patients with a rare inherited disease.

Researchers Jean-Baptiste Roullet and Mike Gibson of the WSU College of Pharmacy and Pharmaceutical Sciences are conducting a natural history study of patients with succinic semialdehyde dehydrogenase deficiency (SSADHD).

SSADHD is a genetic disorder that is most commonly diagnosed in young children; it disrupts the metabolism of gamma-aminobutyric acid (GABA)—a neurotransmitter that serves to inhibit the activity of nerve cells in the brain—and causes a wide … » More …

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