Philip Lazarus
Chair, Pharmaceutical SciencesBoeing Distinguished Professor PBS 431 Spokane

Education

  • Bachelor of Science (Human Genetics, 1981), McGill University, Montreal, Quebec, Canada
  • PhD (Experimental Medicine, 1987), McGill University, Montreal, Quebec, Canada
  • Postdoctoral Fellowship (1987-1990: Laboratory of Nahum Sonenberg, Department of Biochemistry, McGill University, Montreal, Quebec, Canada

Positions

  • Associate Research Scientist; American Health Foundation, Valhalla, NY (1990-1995)
  • Associate Professor; Dept of Pathology, Temple University, Philadelphia, PA (1995-1999)
  • Full Professor; Division of Cancer Control, H. Lee Moffitt Cancer Center/Dept of Biochemistry, University of South Florida, Tampa, FL (1999-2003)
  • Program Leader; H. Lee Moffitt Cancer Center, Tampa, FL (2001-2003)
  • Full Professor; College of Medicine, Penn State University, Hershey, PA (2003-2012)
  • Program Leader and Associate Director; Penn State Cancer Institute (2003-2012)
  • Boeing Distinguished Professor and Chair; Dept of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University (2012-present)

Research

Dr. Lazarus’ research focuses on examining the metabolism of drugs and tobacco constituents including major tobacco carcinogens, and how individual genetic variants play a role in cancer risk and drug toxicity and effectiveness. His laboratory was one of the first to study gene-environment interactions and their role in head and neck as well as lung cancer risk. His studies on nicotine metabolism and differences in nicotine addiction has led to more recent studies developing novel smoking cessation agents. In addition, his laboratory has studied the pharmacogenetics of breast cancer agents including serum estrogen receptor modulators and anti-aromatase inhibitors and has undertaken new studies investigating the potential role of marijuana constituents in drug-drug interactions with opioids and drug addiction and toxicity. Dr. Lazarus is a leader in studies of the UGT phase II family of enzymes and has numerous papers studying their regulation and their role in cancer risk and drug addiction.

Dr. Lazarus has been continuously funded by the National Institutes of Health (USA) since 1995 and has received more than $18.5 million from NIH to date. He has published over 200 peer-reviewed papers, has served both ad hoc and as a full member on several NIH study sections, has served as a reviewer of the NIH intramural research program, serves on the editorial board of Molecular Pharmacology, and has chaired and presented at numerous national and international meetings.

Publications (since 2016)

White JR, Jr, Padowski JM, Zhong Y, Chen G, Luo C, Lazarus P, Layton ME, McPherson S. Pharmacokinetic Analysis and Comparison of Caffeine Administered Rapidly or Slowly in Coffee Chilled or Hot vs. Chilled Energy Drink in Healthy Young Adults. Clin Toxicol (Phila). 2016; 54(4):308-12. PMID: 27100333

Platt A, Xia Z, Liu Y, Chen G, and Lazarus P. Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases. Pharmacogen Genomics. 2016; 26(8):370-80. PMID: 27111237

Chen G, Luo S, Kozlovich S, Lazarus P. Association between Glucuronidation Genotypes and Urinary NNAL Metabolic Phenotypes in Smokers. Cancer Epidemiol Biomarkers Prev. 2016; 25(7):1175-84. PMID: 27197298

Dluzen DF, Sutliff AK, Chen G, Watscon CJ, Ishmail FT, Lazarus P. Regulation of UGT2B expression and activity by miR-216b in liver cancer cell lines. J Pharmacol Exper Ther. 2016; 359:182-193. PMID: 27474751

Chen LS, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Rosenberger A, Aben KK, Andrew AS, Chang SC, Saum KU, Dienemann H, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden EH, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Brüske I, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare MD, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz MR, Amos CI, Bierut LJ. Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes – A Meta-Analysis. EBioMedicine. 2016; 11:219-226. PMID: 27543155

Remsberg CM, Bray BS, Wright SK, Ashmore J, Kabasenche W, Wang S, Lazarus P, Daoud SS. Instructional design and assessment. Design, implementation, and assessment approaches within a pharmacogenomics course. Amer J Pharmaceut Educ. 2017; 81(1):11. PMID: 28289301

Fehringer G, Brenner D, Zhang Z-F, Lee Y-CA, Matsuo K, Lan Q, Vineis P, Stucker I, Boffetta P, Brennan P, Christiani DC, Hong Y-C, Landi MT, Morgenstern H, Schwartz AG, Rennert G, McLaughlin JR, Harris CC, Orlow I, Dios JMB, Raviña AR, Siemiatycki J, Lazarus P, Tardon A, Le Marchand L, Brenner H, Duell EJ, Consonni D, Olsson A, Straif K, Hung R. Alcohol and Lung Cancer Risk Among Never Smokers: A Pooled Analysis from the International Lung Cancer Consortium and the SYNERGY Study. Int J Cancer. 2017; 140(9):1976-1984. PMID: 28120396

Peterson A, Xia Z, Chen G, Lazarus P. In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17β-dihydroexemestane. Pharmacol Res Perspect. 2017; Apr 27;5(3):e00314. PMID: 28603633

Peterson A, Xia Z, Chen G, Lazarus P. Exemestane Potency is unchanged by common nonsynonymous polymorphisms in CYP19A1: Results of a novel anti-aromatase activity assay examining exemestane and its derivatives. Pharmacol Res Perspect. 2017; 5(3):e00313. PMID: 28603632

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley K, Qian DC, Ji X, Liu G, Timofeeva M, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong Y-C, Yuan J-M, Bertazzi PA, Pesator AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Brüske I, Wichmann H-E, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao M-S, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh W-P, Gao Y-T, Houlston R, McLaughlin J, Stevens V, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV, SpiroMeta Consortium, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI. Large-scale association analysis identifies new lung cancer succeptibility loci and heterogeneity in genectic succepibility across histological subtypes. Nature Gen. 2017; Jul, 49(7):1126-1132. PMID: 28604730

Laube BL, Afshar-Mohajer N, Koehler K, Chen G, Lazarus P, Collaco JM, McGrath-Morrow SA. Acute and Chronic in Vivo Effects of Exposure to Nicotine and Propylene Glycol from an E-cigarette on Mucociliary Clearance in a Murine Model. Inhal Toxicol. 2017; Apr, 29(5):197-205. PMID: 28651446

Carreras-Torres R; Johansson M; Haycock PC; Wade KH; Relton CL; Martin RM; Smith GD; Albanes D; Aldrich MC; Andrew A; Arnold SM; Bickeböller H; Bojesen SE; Brunnström H; Manjer J; Brüske I; Caporaso NE; Chen C; Christiani DC; Christian WJ; Doherty JA; Duell EJ; Field JK; Davies MPA; Marcus MW; Goodman GE; Grankvist K; Haugen A; Hong Y-C; Kiemeney LA; van der Heijden EHFM; Kraft P; Johansson MB; Lam S; Landi MT; Lazarus P; Le Marchand L; Liu G; Melander O; Park SL; Rennert G; Risch A; Haura EB; Schabath MB; Shen H; Tardon A; Teare MD; Woll P; Tsao M-S; Wu X; Yuan J-M; Hung RJ; Amos CI; McKay J; Brennan P. Obesity, Metabolic Factors and Risk of Different Histological Types of Lung Cancer: A Mendelian Randomization Study. PLOS One. 2017; Jun 8, 12(6):e0177875. PMID: 28594918

Wang T; Moon J-Y; Wu Y; Amos CI; Hung RJ; Tardon A; Andrew A; Chen C; Christiani DC; Albanes D; van der Heijden EHFM; Duell E; Rennert G; Goodman G; Liu G; Mckay JD; Yuan J-M; Field JK; Manjer J; Grankvist K; Kiemeney LA; Le Marchand L; Teare MD; Schabath MB; Johansson M; Aldrich MC; Davies M; Johansson M; Tsao M-S; Caporaso N; Lazarus P; Lam S; Bojesen SE; Arnold S; Wu X; Zong X; Hong Y-C; Ho GYF. Pleiotropy of Genetic Variants on Obesity and Smoking Phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium. PLOS Genetics. 2017; Sep 28;12(9):e0185660. PMID: 28957450

Huang J, Liu Y, Vitale S, Penning TM, Whitehead AS, Blair IA, Vachani A, Clapper ML, Muscat JE, Lazarus P, Scheet P, Moore JH, Chen Y. On meta- and mega-analyses for gene-environment interactions Genetic Epidemiol. 2017; Nov, 41(8):876-886. PMID: 29110346.

Li Y, Xiao X, Han Y, Gorlova O, Qian D, Leighl N, Johansen JS, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Wichmann HE, Manz J, Muley T, Risch A, Rosenberger A, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Houlston R, Artigas MS, Grankvist K, Johansson M, Shepherd FA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Liu G, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Bertazzi PA, Pesatori AC, Christiani DC, Caporaso N, Johansson M, McKay JD, Brennan P, Hung RJ, Amos CI. Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population. Carcinogenesis. 2018; Mar 8, 39(3):336-346. PMID: 29059373

Luo S, Chen G, Truica C, Baird CC, Leitzel K, Lazarus P. Role of the UGT2B17 deletion in exemestane pharmacogenetics. Pharmacogen J. 2018; Apr, 18(2):295-300. PMID: 28534527.

Denton TT, Srivastava P, Xia Z, Chen G, Watson C, Wynd A, Lazarus P. Identification of the 4-position of 3-alkynyl and 3-heteroaromatic substituted pyridine methanamines as a key modification site eliciting increased potency and enhanced selectivity for cytochrome P-450 2A6 inhibition. J Med Chem. 2018; Aug 23, 61(16):7065-7086. PMID: 29995408.

Ji X, Bossé Y, Landi MT, Gui J, Xiao X,Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, McKay J, Zong X, Carreras-Torres R, Christiani D, Caporaso N, Johansson M, Qian DC, Liu G, Bojesen SE, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew A, Shen H, Hong Y-C, Yuan J-M, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overva K, Trichopoulou A, Tumino R, Barnett M, Doherty J, Goodman G, Cox A, Taylor F, Woll P, Brüske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell Ej, Butler LM, Koh W-P, Gao Y-T, Houlston R, McLaughlin J, Stevens, V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, SpiroMeta Consortium, Hancock DB, Bierut LJ, Gaddis NC, Lutz SM, Gu F, Johnson EO, Byun J, Kamal A, Zhu D, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Chanock S, Brennan P, Amos CI. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nature Commun. 2018; Aug 13, 9(1):3221. PMID: 30104567.

Rosenberger A, Hung RJ, Christiani DC, Caporaso NE, Liu G, Bojesen SE, Le Marchand L, Haiman C, Demetrius A, Aldrich, MC, Tardon A, Fernández-Tardón G, Rennert G, Field JK, Kiemeney K, Lazarus P, Haugen A, Zienolddiny S, Lam S, Schabath MB, Andrew AS, Brunnström H, Goodman GE, Doherty JA, Chen C, Teare MT, Wichmann H-E, Manz J, Risch A, Muley TR, Johansson M, Brennan P, Landi MT, Amos CI, Pesch B, Johnen G, Brüning T, Bickeböller H, Gomolka M. Genetic modifiers of radon induced lung cancer risk – A genome-wide in-teraction study in former uranium miners. Int Arch Occup Environ Health. 2018; Nov, 91(8):937-950. PMID: 29971594.

Ferreiro-Iglesias A, Lesseur C, McKay J, Hung R, Han Y, Zong X, Christiani D, Johansson M, Xiao X, Li Y, Qian D, Ji X, Liu G, Caporaso N, Scelo G, Zaridze D, Moukeria A, Kontic M, Ognjanovic S, Lissowska J, Szołkowska M, Swiatkowska B, Janout V, Holcatova I, Bolca C, Savic M, Ognjanovic M, Bojesen S, Wu X, Albanes D, Aldrich M, Tardon A, Fernandez-Somoano A, Fernandez-Tardon G, Le Marchand L, Rennert G, Chen C, Doherty J, Goodman G, Bickeböller H, Wichmann H-E, Risch A, Rosenberger A, Shen H, Dai J, Field J, Davies M, Woll P, Teare MD, Kiemeney L, van der Heijden E, Yuan J-M, Hong Y-C, Haugen A, Zienolddiny S, Lam SL, Tsao M-S, Johansson M, Grankvist K, Schabath M, Andrew A, Duell E, Melander O, Brunnstrom H, Lazarus P, Arnold S, Slone S, Byun J, Kamal A, Zhu D, Landi M, Amos C, Brennan P. Fine-mapping of the MHC region identifies different independent variants influencing susceptibility to lung cancer in Europeans and Asians. Nature Commun. 2018; Sep 25, 9(1):3927. PMID: 30254314.

Luo S, Chen G, Truica CI, Baird CC, Xia Z, Lazarus P. Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane. Drug Metab Dispos. 2018; Dec, 46(12):1867-1878. PMID: 30257855.

Voltzke KJ, Lee Y-CA2, Zhang Z-F, Zevallos JP, Yu G-P, Winn DB, Vaughan TL, Sturgis EM, Smith E, Schwartz SM, Schantz S, Muscat J, Morgenstern H, McClean M, Li G, Lazarus P, Kelsey K, Gillison M, Chen C, Boffetta P, Hashibe M, Olshan AF. Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: Pooled analysis of US studies in the INHANCE Consortium. Cancer Causes Cont. 2018; Jul, 29(7):619-630. PMID: 29761303.

Ashmore JH, Luo S, Watson C, and Lazarus P. Carbonyl reduction of NNK by recombinant human lung enzymes. Identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung. Carcinogenesis. 2018; Jul 30, 39(8):1079-1088. PMID: 29788210.

Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe J, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold S, Aronson KJ, Arun BK, Bandera EV, Barkardottir RB, Barnes DR, Batra J, Beckmann MW, Benitez J, Benlloch S, Berchuck A, Berndt SI, Bickeboller H, Bien SA, Blomqvist C, Boccia S, Bogdanova NV, Bojesen SE, Bolla MK, Brauch H, Brenner H, Brenton J, Brook M, Brunet J, Brunnström H, Buchanan DD, Burwinkel B, Butzow R, Cadoni G, Caldés T, Caligo MA, Campbell I, Campbell PT, Cancel-Tassin G, Cannon-Albright L, Canzian F, Caporaso N, Carvalho AL, Chan AT, Chang-Claude J, Chanock SJ, Chen C, Christiani DC, Claes KBM, Claessens F, Clements J, Collée JM, Correa MC, Couch FJ, Cox A, Cunningham JM, Cybulski C, Czene K, Daly MB, deFazio A, Devilee P, Diez O, Gago-Dominguez M, Donovan JL, Dörk T, Duell EJ, Dunning AM, Dwek M, Eccles DM, Edlund CK, Velez Edwards DR, Ellberg C, Evans DG, Fasching PA, Ferris RL, Liloglou T, Figueiredo JC, Fletcher O, Fortner RT, Fostira F, Franceschi S, Friedman E, Gallinger SJ, Ganz PA, Garber J, García-Sáenz JA, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Goode EL, Goodman MT, Goodman G, Grankvist K, Greene MH, Gronberg H, Gronwald J, Guénel P, Håkansson N, Hall P, Hamann U, Hamdy FC, Hamilton RJ, Hampe J, Haugen A, Heitz F, Herrero R, Hillemanns P, Hoffmeister M, Høgdall E, Hong Y-C, Hopper JL, Houlston R, Hulick PJ, Hunter DJ, Huntsman DG, Idos G, Imyanitov EN, Ingles SA, Isaacs C, Jacobs EJ, Jakubowska A, James P, Jenkins MA, Johansson M, Johansson M, John EM, Joshi A, Kaneva R, Karlan BY, Kelemen LE, Kühl T, Khaw K-T, Khusnutdinova E, Kibel AS, Kiemeney LA, Kim J, Kjaer SK, Knight JA, Kogevinas M, Kote-Jarai Z, Koutros S, Kristensen VN, Kupryjanczyk J, Lacko M, Lam S, Lambrechts D, Landi MT, Lazarus P, Le ND, Lee E, Lejbkowicz F, Lenz H-J, Leslie G, Lessel D, Lester J, Levine DA, Li L, Li CI, Lindblom A, Lindor NM, Liu G, Loupakis F, Lubiński J, Maehle L, Maier C, Mannermaa A, Le Marchand L, Margolin S, May T, McGuffog L, Meindl A, Middha P, Miller A, Milne RL, Maclnnis RJ, Modugno F, Montagna M, Moreno V, Moysich KB, Mucci L, Muir K, Mulligan AM, Nathanson KL, Neal DE, Ness AR, Neuhausen SL, Nevanlinna H, Newcomb PA,21,43 Lisa F. Newcomb LF, Nielsen FC, Nikitina-Zake L, Nordestgaard BG, Nussbaum RL, Offit K, Olah E, Al Olama AA, Olopade OI, Olshan AF, Olsson H, Osorio A, Pandha H, Park JY, Pashayan N, Parsons MT, Pejovic T, Penney KL, Peters WHM, Phelan CM, Phipps AI, Plaseska-Karanfilska D, Pring M, Prokofieva D, Radice P, Stefansson K, Ramus SJ, Raskin L, Rennert G, Rennert HS, van Rensburg EJ, Riggan MJ, Risch HA, Risch A, Roobol MJ, Rosenstein BS, Rossing MA, De Ruyck K, Saloustros E, Sandler DP, Sawyer EJ, Schabath MB, Schleutker J, Schmidt MK, Setiawan VW, Shen H, Siegel EM, Sieh W, Singer CF, Slattery ML, Sorensen KD, Southey MC, Spurdle AB, Stanford JL, Stevens VL, Stintzing S, Stone J, Sundfeldt K, Sutphen R, Swerdlow AJ, Tajara EH, Tangen CM, Tardon A, Taylor JA, Teare MD, Teixeira MR, Terry MB, Terry KL, Thibodeau SN, Thomassen M, Bjørge L, Tischkowitz M, Toland AE, Torres D, Townsend PA, Travis RC, Tung N, Tworoger SS, Ulrich CM, Usmani N, Vachon C, Van Nieuwenhuysen E, Vega A, Aguado-Barrera ME, Wang Q, Webb PM, Weinberg CR, Weinstein S, Weissler MC, Weitzel JN, West C, White E, Whittemore AS, Wichmann H-E, Wiklund F, Winqvist R, Wolk A, Woll P, Woods M, Wu AH, Wu X, Yannoukakos D, Zheng W, Zienolddiny S, Ziogas A, Zorn KK, Thomas D, Hung RJ, Diergaarde B, McKay J, Peters U, Hsu L, García-Closas M, Eeles RA, Chenevix-Trench G, Brennan PB, Haiman CA, Simard J, Easton DF, Gruber SB, Pharoah PDP, Price AL, Pasaniuc B, Amos CI, Kraft P, Lindström S. APCB BioResource, Mod SQuaD study collaborators, GC-HBOC study collaborators, CONSIT TEAM study collaborators, GEMO Study collaborators, EMBRACE, HEBON Investigators, BCFR Investigators, ABCTB Investigators, kConFab/AOCS Investigators, SWE-BRCA. Shared heritability and functional enrichment among breast, colorectal, head and neck, lung, ovary and prostate cancer. Nature Commun. 2019; Jan 25, 10(1):431. PMID: 30683880.

Brenner DR, Fehringer G, Zhang ZF, Lee YA, Meyers T, Matsuo K, Ito H, Vineis P, Stucker I, Boffetta P, Brennan P, Christiani DC, Diao N, Hong YC, Landi MT, Morgenstern H, Schwartz AG, Rennert G, Saliba W, McLaughlin JR, Harris CC, Orlow I, Barros Dios JM, Ruano Raviña A, Siemiatycki J, Koushik A, Cote M, Lazarus P, Fernandez-Tardon G, Tardon A, Le Marchand L, Brenner H, Saum KU, Duell EJ, Andrew AS, Consonni D, Olsson A, Hung RJ, Straif K. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study. Cancer Epidemiol. 2019; Feb, 58:25-32. PMID: 30445228.

Perez-Paramo YX, Chen G, Ashmore JH, Watson CJW, Nasrin S, Adams-Haduch J, Wang R, Gao Y-T, Koh W-P, Yuan J-M, Lazarus P. Nicotine-N’-oxidation by flavin monooxygenase enzymes. Cancer Epidmiol Biomarkers Prev. 2019 Feb, 28(2):311-320. PMID: 30381441. Chosen as ‘Authors Choice’ for this issue of Cancer Epidmiol Biomarkers Prev.

Li Y, Xiao X, Bossé Y, Gorlova O, Gorlov I, Han Y, Byun J, Leighl N, Johansen J, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Wichmann H-E, Manz J, Muley T, Risch A, Rosenberger A, Han J, Siminovitch K, Arnold S, Haura E, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski T, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell E, Butler L, Houlston R, Artigas M, Grankvist K, Johansson M, Shepherd F, Marcus M, Brunnström H, Manjer J, Melander O, Muller D, Overvad K, Trichopoulou A, Tumino R, Liu G, Bojesen S, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich M, Bush W, Tardon A, Rennert G, Teare D, Field J, Kiemeney L, Lazarus P, Haugen A, Lam S, Schabath M, Andrew A, Bertazzi PA, Pesatori A, Christiani D, Caporaso N, Johansson M, McKay J, Brennan P, Hung R, and Amos C. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development. Oncotarget 2019; Mar 5, 10(19):1760-1774. PMID: 30956756.

Dai J, Li Z, Amos CI, Hung RJ, Tardon A, Andrew A, Chen C, Christiani DC, Albanes D, van der Heijden EHFM, Duell E, Rennert G, Mckay JD, Yuan J-M, Field JK, Manjer J, Grankvist K, Marchand LL, Teare MD, Schabath MB, Aldrich MC, Tsao M-S, Lazarus P, Lam S, Bojesen SE, Arnold S, Wu X, Hu Z, Shen H. Systematic analyses of regulatory variants in DNase I hypersensitive regions identified in two novel lung cancer susceptibility loci. Carcinogenesis. 2019; May 14, 40(3):432-440. PMID: 30590402.

Zhu Y, Wei Y, Zhang R, Dong X, Shen S, Zhao Y, Bai J, Albanes D, Caporaso NE, Landi MT, Zhu B, Chanock SJ, Gu F, Lam S, Tsao M-S, Shepherd FA, Tardon A, Fernández-Somoano A, Fernandez-Tardon G, Chen C, Barnett MJ, Doherty J, Bojesen SE, Johansson M, Brennan P, McKay JD, Carreras-Torres R, Muley T, Risch A, Wichmann HE, Bickeboeller H, Rosenberger A, Rennert G, Saliba W, Arnold SM, Field JK, Davies MPA, Marcus MW, Wu X, Ye Y, Marchand LL, Wilkens LR, Melander O, Manjer J, Brunnström H, Hung RJ, Liu G, Brhane Y, Kachuri L, Andrew AS, Duell EJ, Kiemeney LA, van der Heijden HFM, Haugen A, Zienolddiny S, Skaug V, Grankvist K, Johansson M, Woll PJ, Cox A, Taylor F, Teare DM, Lazarus P, Schabath MB, Aldrich MC, Houlston RS, McLaughlin J, Stevens VL, Shen H, Hu Z, Dai J, Amos CI, Han Y, Zhu D, Goodman GE, Chen F, Christiani DC. Elevated platelet count appears to be causally associated with increased risk of lung cancer: A Mendelian randomization analysis. Cancer Epidmiol Biomarkers Prev. 2019; May, 28(5):935-942. PMID: 30700444.

Sutliff AK, Watson CJW, Chen G, Lazarus P. Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p. J Pharmacol Exper Ther. 2019; May, 369(2):234-243. PMID: 30850392.

Liu SN, Lu JBL, Watson CJW, Lazarus P, Desta Z, Gufford BT. Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors. Drug Metab Dispos. Feb 25, 2019; May, 47(5):535-544. PMID: 30804050.

Di Credico G, Edefonti V, Polesel J, Pauli F, Torelli N, Serraino D, Negri E, Luce D, Stucker I, Matsuo K, Brennan P, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt AW, Koifman R, Wunsch-Filho V, Holcatova I, Ahrens W, Lagiou P, Simonato L, Richiardi L, Healy C, Kjaerheim K, Conway DI, Macfarlane TV, Thomson P, Agudo A, Znaor A, Boaventura Rios LF, Toporcov TN, Franceschi S, Herrero R, Muscat J, Olshan AF, Zevallos JP, La Vecchia C, Winn DM, Sturgis EM, Li G, Fabianova E, Lissowska J, Mates D, Rudnai P, Shangina O, Swiatkowska B, Moysich K, Zhang ZF, Morgenstern H, Levi F, Smith E, Lazarus P, Bosetti C, Garavello W, Kelsey K, McClean M, Ramroth H, Chen C, Schwartz SM, Vaughan TL, Zheng T, Menvielle G, Boccia S, Cadoni G, Hayes RB, Purdue M, Gillison M, Schantz S, Yu GP, Brenner H, D’Souza G, Gross ND, Chuang SC, Boffetta P, Hashibe M, Lee YA, Dal Maso L. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.Oral Oncol. 2019; Jul, 94:47-57. PMID: 31178212.

Kachuri L, Saarela O, Bojesen SE, Smith GD, Liu G, Landi MT, Caporaso NE, Christiani DC, Johansson M, Panico S, Overvad K, Trichopoulou A, Vineis P, Scelo G, Wu X, Albanes D, Diergaarde B, Lagiou P, Macfarlane GJ, Aldrich MC, Tardón A, Rennert G, Olshan AF, Weissler MC, Chen C, Goodman GE, Doherty JA, Ness AR, Bickeböller H, Field JK, Teare MD, Kiemeney LA, Haugen A, Wünsch-Filho V, Tajara EH, Lam S, Neto JE, Lacko M, Peters WHM, Le Marchand L, Duell EJ, Andrew AS, Franceschi S, Majer J, Arnold S, Lazarus P, Zaridze D, Mates D, Lissowska J, Boccia S, Schabath MB, Lesseur C, Sun L, Zong X, McKay JD, Brennan P, Amos CI, Hung RJ. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. Int J Epidemiol. 2019; Jun 1, 48(3):751-766. PMID: 30059977.

Hung R, Spitz M, Houlston R, Schwartz A, Field J, Ying J, Li Y, Han Y, Ji X, Chen W, Wu X, Gorlov I, Na J, de Andrade M, Liu G, Brhane Y, Diao N, Wenzlaff A, Davies M, Liloglou T, Timofeeva M, Muley T, Rennert H, Saliba W, Ryan B, Bowman E, Barros-Dios JM, Perez-Rios M, Morgenstern H, Zienolddiny S, Skaug V, Ugolini D, Bonassi S, van der Heijden EHFM, Tardon A, Bojesen SE, Landi MT, Johansson M, Bickeboller H, Arnold S, Le Marchand L, Melander O, Andrew A, Grankvist K, Caporaso N, Teare MD, Schabath MB, Aldrich M, Kiemeney L, Wichmann H-E, Lazarus P, Mayordomo J, Neri M, Haugen A, Zhang Z-F, Ruano-Ravina A, Brenner H, Harris C, Orlow I, Rennert G, Risch A, Brennan P, Christiani D, Amos C, Yang P, Gorlova O. Lung cancer risk in never smokers of European descent is associated with genetic variation in the 5p15.33 TERT/CLPTM1L region. J. Thoracic Oncol. 2019; Aug;14(8):1360-1369. PMID: 31009812.

Kozlovich S, Chen G, Watson CJW, Lazarus P. Prominent Stereoselectivity of NNAL Glucuronidation in Head and Neck Tissues. Chem Res Toxicol. 2019; Aug 19, 32(8):1689-1698. PMID: 31307193.

Kozlovich S, Chen G, Watson CJW, Blot WJ, Lazarus P. The role of L- and D-menthol in the glucuronidation and detoxification of the major lung carcinogen, NNK. Drug Metab Dispos. 2019; 47:1388–1396. PMID: 31578206.

Sutliff AK, Shi J, Watson CJW, Hunt M, Chen G, Zhu H, Lazarus P. Regulation of UGT2B10 and UGT2B7 by miR-485-5p in human liver. Mol Pharmacol. 2019; Dec 96(6):674-682. PMID: 31554697.

Lee Y-CA, Al-Temimi M, Ying J, Muscat J, Olshan AF, Zevallos JP, Winn DM, Li G, Sturgis EM, Morgenstern H, Zhang Z-F, Smith E, Kelsey K, McClean M, Vaughan TL, Lazarus P, Chen C, Schwartz SM, Gillison M, Schantz S, Yu G-P, D’Souza G, Gross N, Monroe M, Kim J, Hashibe M. Head and neck cancer risk prediction models for the U.S. population from the INHANCE consortium. Amer J Epidemiol. 2019; Nov 29. pii: kwz259. doi: 10.1093/aje/kwz259. [Epub ahead of print]. PMID: 31781743.

Neumiller JJ, Chen G, Newsome C, Hughes S, Lazarus P, White JR, Jr Assessment of Regular and NPH Insulin Concentration via Two Methods of Quantification: The Washington State Insulin Concentration Study (WICS). J Diabetes Science Technol. 2019; Oct 22:1932296819883291. doi: 10.1177/1932296819883291. [Epub ahead of print] PMID: 31640422.

Chang CP, Chang SC, Chuang SC, Berthiller J, Ferro G, Matsuo K, Wünsch-Filho V, Toporcov TN, de Carvalho MB, La Vecchia C, Olshan AF, Zevallos JP, Serraino D, Muscat J, Sturgis EM, Li G, Morgenstern H, Levi F, Dal Maso L, Smith E, Kelsey K, McClean M, Vaughan TL, Lazarus P, Ramroth H, Chen C, Schwartz SM, Winn DM, Bosetti C, Edefonti V, Garavello W, Negri E, Hayes RB, Purdue MP, Boccia S, Cadoni G, Shangina O, Koifman R, Curado MP, Vilensky M, Swiatkowska B, Herrero R, Franceschi S, Benhamou S, Fernandez L, Menezes AMB, Daudt AW, Mates D, Schantz S, Yu GP, Lissowska J, Brenner H, Fabianova E, Rudnai P, Brennan P, Boffetta P, Zhang ZF, Hashibe M, Lee YA. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE). Cancer Epidemiol. 2019; Dec 63:101615. doi:10.1016/j.canep.2019.101615. [Epub ahead of print]. PMID: 31586822.

Dai J, Huang M, Amos C, Hung R, Tardon A, Andrew A, Chen C, Christiani D, Albanes D, van der Heijden E, Duell E, Rennert G, Goodman G, Liu G, McKay J, Yuan J-M, Field J, Manjer J, Grankvist K, Kiemeney L, Le Marchand L, Teare MD, Schabath M, Johansson M, Aldrich M, Davies M, Johansson M, Tsao M-S, Caporaso N, Lazarus P, Lam S, Bojesen S, Arnold S, Wu X, Kontic M, Hu Z. Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk. Int J Cancer. 2020; 146:2855-2864. PMID: 31577861.

Bossé Y, Li Z, Manem V, Torres RC, Gaudreault N, Albanes D, Aldrich MC, Andrew A, Arnold S, Bickeboller H, Bojesen SE, Brennan P, Brunnstrom H, Caporaso N, Chen C, Christiani DC, Field JK, Goodman G, Grankvist K, Houlston R, Hung RJ, Johansson M, Johansson M, Kiemeney LA, Lam S, Landi MT, Lazarus P, Le Marchand L, Liu G, Melander O, Rennert G, Risch A, Schabath MB, Shete S, Stevens LV, Tardon A, Wichmann H-E, Woll P, Zienolddiny S, Obeidat M, Timens W, Joubert P, Amos CI, McKay JD. Transcriptome-wide association study reveals candidate causal genes for lung cancer. Int J Cancer. 2020; Apr 1, 146(7):1862-1878. doi: 10.1002/ijc.32771. Epub 2019 Dec 9. PMID: 31696517.

Chen Y-C, Fowler JP, Wang J, Watson, CJW, Staben A, Sherafat Y, Lazarus P*, Denton TT*, Fowler CD* (*Co-corresponding authors). The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. J Pharmacol Exper Ther. 2020; Jan 372(1):21-29. PMID: 31628204.

Kachuri L, Johansson M, Rashkin S, Graff R, Bossé Y, Manem V, Caporaso N, Landi M, Christiani D, Vineis P, Liu G, Scelo G, Zaridze D, Shete S, Albanes D, Aldrich M, Tardon A, Rennert G, Chen C, Goodman G, Doherty JA, Bickeböller H, Field J, Davies M, Teare MD, Kiemeney L, Bojesen S, Hugen A, Zienolddiny S, Lam S, Le Marchand L, Cheng I, Schabath M, Duell E, Andrew A, Manjer J , Lazarus P, Arnold S, McKay J, Emami N, Warkentin M, Brhane Y, Obeidat M, Martin R, Relton C, Smith GD, Haycock P, Amos C, Brennan P, Witte J, Hung R. Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nature Commun. 2020; Jan 7, 11(1):27; doi.org/10.1038/s41467-019-13855-2. PMID: 31911640. (Chosen as an Editor Highlight)

Vergara AG, Watson CJW, Chen G, Lazarus P. UDP-glycosyltransferase 3A (UGT3A) metabolism of polycyclic aromatic hydrocarbons: potential importance in aerodigestive tract tissues. Drug Metab Dispos. 2020 Mar;48(3):160-168. PMID: 31836608.

Ji X, Mukherjee S, Landi MT, Bosse Y, Joubert P, Zhu D, Gorlov I, Xiao X, Han Y, Gorlova O, Hung RJ, Wu X, Carreras-Torres R, Christiani DC, Caporaso N, Johansson M, Liu G, Whitfield M, Bojesen SE, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Chen C, Teare MD, Field JK, Kiemeney LA, Lazarus P, Zienolddiny S, Lam S, Schabath MB, Andrew AS, Shen H, Hong Y-C, Yuan J-M, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman C, Wilkens L, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden EHFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty J, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Manz J, Muley T, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd F, Tsao M-S, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh W-P, Gao Y-T, Houlston R, McLaughlin J, Stevens V, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Artigas MS, Tobin MD, Wain LV, Gu F, Brenner H, Chanock S, Brennan P, The OncoArray Lung Cancer Consortium, McKay J, Amos CI. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nature Commun. 2020; May 11, 11(1):2220. PMID: 32393777.

Lee Y-CA, Al-Temimi M, Ying J, Muscat J, Olshan AF, Zevallos JP, Winn DM, Li G, Sturgis EM, Morgenstern H, Zhang Z-F, Smith E, Kelsey K, McClean M, Vaughan TL, Lazarus P, Chen C, Schwartz SM, Gillison M, Schantz S, Yu G-P, D’Souza G, Gross N, Monroe M, Kim J, Hashibe H. Head and neck cancer risk prediction models from the INHANCE consortium. Amer J Epidemiol. 2020; Apr 2, 189(4):330-342. PMID: 31781743.

Wang Y, Gorlova OY, Gorlov IP, Zhu M, Dai J, Albanes D, Lam S, Tardon A, Chen C, Goodman GE, Bojesen SE, Landi MT, Johansson M, Risch A, Wichmann H-E, Bickeböller H, Christiani DC, Rennert G, Arnold SM, Brennan P, Field JK, Shete S, Le Marchand L, Melander O, Brunnström H, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Zienolddiny S, Grankvist K, Johansson M, Caporaso NE, Woll PJ, Lazarus P, Schabath MB, Aldrich MC, Stevens VL, Ma H, Jin G, Hu Z, Amos CI, Shen H. Association analysis of driver-gene related genetic variants identified novel lung cancer susceptibility loci with 20,871 lung cancer cases and 15,971 controls. Cancer Epidemiol Biomarkers Prev. 2020; Jul, 29(7):1423-1429. PMID: 32277007.

Borrego-Soto G, Perez-Paramo YX, Chen G, Santuario-Facio SK, Santos-Guzman J, Posadas-Valay R, Alvarado-Monroy FM, Balderas-Renteria I, Ortiz-Lopez R, Lazarus P, Rojas-Martinez A. Genetic Variants in CYP2A6 and UGT1A Genes Associated with Urinary Nicotine Metabolites in Young Mexican Smokers. The Pharmacogenomics J. 2020; Aug, 20(4):586-594. PMID: 31959879.

Nasrin S, Chen G, Watson CJW, Lazarus P. High levels of tobacco-specific N-nitrosamines in Bangladeshi smokeless tobacco products. PLOS One. 2020; May 26,15(5):e0233111. doi: 10.1371/journal.pone.0233111. eCollection 2020. PMID: 32453764.

Gaither K, Watson CJW, Liu D, Lazarus P. Expression of activating transcription factor 5 (ATF5) is mediated by microRNA-520b under diverse cellular stress in cancer cells. PLOS One. 2020; Jun 30,15(6):e0225044. doi: 10.1371/journal.pone.0225044. eCollection. PMID: 32603335

Ho V, Pasquet R, Luo S, Chen G, Goss P, Tu D, Lazarus P, Richardson H. Variation in the UGT2B17 genotype, exemestane metabolism and menopauserelated toxicities in the CCTG MAP.3 trial. Breast Cancer Res Treat. 2020; Oct; 183(3):705-716 PMID: 32715442.

Di Credico G, Polesel J, Dal Maso L, Pauli F, Torelli N, Luce D, Radoï L, Matsuo K, Serraino D, Brennan P, Holcatova I, Ahrens W, Lagiou P, Canova C, Richiardi L, Healy C, Kjaerheim K, Conway DI, Macfarlane GJ, Thomson P, Agudo A, Znaor A, Franceschi S, Herrero R, Toporcov TN, Moyses RA, Muscat J, Negri E, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt AW, Koifman R, Wunsch-Filho V, Olshan AF, Zevallos JP, Sturgis EM, Li G, Levi F, Zhang Z-F, Morgenstern H, Smith E, Lazarus P, La Vecchia C, Garavello W, Chen C, Schwartz SM, Zheng T, Vaughan TL, Kelsey K, McClean M, Benhamou S, Hayes RB, Purdue M, Gillison M, Schantz S, Yu G-P, Chuang S-C, Boffetta P, Hashibe M, Lee Y-CA, Edefonti V. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. British J Cancer. 2020; 123:1456-1463. PMID: 32830199.

Qin N, Li Y, Wang C, Zhu M, Dai J, Hong T, Albanes D, Lam S, Tardon A, Chen C, Goodman G, Bojesen SE, Landi MT, Johansson M, Risch A, Wichmann HE, Bickeboller H, Rennert G, Arnold S, Brennan P, Field JK, Shete S, Le Marchand L, Melander O, Brunnstrom H, Liu G, Hung RJ, Andrew A, Kiemeney LA, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Woll P, Lazarus P, Schabath MB, Aldrich MC, Stevens VL, Jin G, Christiani DC, Hu Z, Amos CI, Ma H, Shen H. Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma. Front Med. 2020; Sep 5, doi: 10.1007/s11684-020-0779-4. Online ahead of print. PMID: 32889700.

Vergara AG, Watson CJW, Watson JM, Chen G, Lazarus P. Altered metabolism of polycyclic aromatic hydrocarbons by UDP-glycosyltransferase 3A2 (UGT3A2) missense variants. Chem Res Toxicol. 2020; Nov 16, 33(11):2854-2862. PMID: 32993298.

Bravi F, Yuan-Chin AL, Hashibe M, Boffetta P, Conway DI, Ferraroni M, La Vecchia C, and Edefonti V on behalf of the INHANCE Consortium investigators including (in alphabetical order): Agudo A, Ahrens W, Benhamou S, Boccia S, Brennan P, Brenner H, Cadon G, Canova C, Chen C, Chuang S-C, Curado MP, Dal Maso L, Daudt AW, D’Souza G, Fabianova E, Fernandez L, Franceschi S, Garavello W, Gillison M, Gross ND, Hayes RB, Healy C, Herrero R, Holcatova I, Kelsey K, Kjaerheim K, Koifman R, Lagiou P, Lazarus P, Levi F, Li G, Lissowska J, Luce D, Macfarlane GJ, Mates D, Matsuo K, McClean M, Menezes A, Menvielle G, Morgenstern H, Moyses RA, Moysich K, Muscat J, Negri E, Olshan AF, Pandics T, Polesel J, Purdue MP, Radoï L, Ramroth H, Richiardi L, Schantz S, Schwartz SM, Serraino D, Shangina O, Smith E, Sturgis EM, Świątkowska B, Thomson P, Toporcov TN, Vaughan TL, Vilensky M, Winn DM, Wunsch-Filho V, Yu G-P, Zevallos JP, Zhang Z-F, Zheng T, Znaor A. Lessons learned from the INHANCE consortium: an overview of recent results on head and neck cancer. Oral Dis. 2021; Jan, 27(1):73-93. PMID: 32569410.

Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, Bosse Y, Lam S, Tsao M-S, Tardon A, Chen C, Doherty J, Goodman G, Bojesen S, Landi M, Johansson M, Field J, Bickeboller H, Wichmann H-E, Risch A, Rennert G, Arnold S, Wu X, Melander O, Brunnstrom H, Le Marchand L, Liu G, Andrew A, Duell E, Kiemeney L, Shen H, Haugen A, Johansson M, Grankvist K, Caporaso N, Woll P, Teare M, Scelo G, Hong Y-C, Yuan J-M, Lazarus P, Schabath M, Aldrich M, Albanes D, Mak R, Barbie D, Brennan P, Hung R, Amos C, Christiani D, Lin X. Integration of Multi-Omic Annotation Data to Prioritize and Characterize Inflammation and Immune-Related Risk Variants in Squamous Cell Lung Cancer. Genetic Epidemiol. 2021; Feb, 45(1):99-114. PMID: 32924180.

Zhou W, Liu G, Hung RJ, Haycock PC, Aldrich MC, Andrew AS, Arnold SM, Bickeböller H, Bojesen SE, Brennan P, Brunnström H, Melander O, Caporaso NE, Landi MT, Chen C, Goodman GE, Christiani DC, Cox A, Field JK, Johansson M, Kiemeney LA, Lam S, Lazarus P, Le Marchand L, Rennert G, Risch A, Schabath MB, Shete SS, Tardón A, Zienolddiny S, Shen H, Amos CI. Causal Relationships between Body Mass Index, Smoking, and Lung Cancer: Univariable and Multivariable Mendelian Randomization. Cancer Epidemiol. 2021; Mar 1, 148(5):1077-1086. PMID: 32914876.

Perez-Paramo YX and Lazarus P. Pharmacogenetics factors influencing smoking cessation success; the importance of nicotine metabolism. Expert Opin Drug Metabol Toxicol. 2020; Dec 29:1-17. doi: 10.1080/17425255.2021.1863948. Online ahead of print. PMID: 33322962.

Hung R, Warkentin M, Brhane Y, Chatterjee N, Christiani D, Landi MT, Caporaso N, Liu G, Johansson M, Albanes D, Le Marchand L, Tardon A, Rennert G, Bojesen S, Chen C, Field J, Kiemeney L, Lazarus P, Zienolddiny S, Lam S, Andrew A, Arnold S, Aldrich M, Bickeböller H, Risch A, Schabath M, McKay J, Brennan P, Amos C. Assessing Lung Cancer Absolute Risk Trajectory based on Polygenic Risk Model. Cancer Res. 2021; Jan 20:canres.1237.2020. doi: 10.1158/0008-5472.CAN-20-1237. Online ahead of print. PMID: 33472890.

Lesseur C, Ferreiro-Iglesias A, McKay JD, Bossé Y, Johansson MJ, Gaborieau V, Landi MT, Christiani DC, Caporaso NC, Bojesen SE, Amos CI, Shete S, Liu G, Rennert G, Albanes D, Aldrich MC, Tardon A, Chen C, Triantafillos L, Field JK, Teare MD, Kiemeney LA, Diergaarde B, Ferris R, Zienolddiny S, Lam S, Olshan AF, Weissler MC, Lacko M, Risch A, Bickeböller H, Ness AR, Thomas S, Le Marchand L, Schabath MB, Wünsch-Filho V, Tajara EH, Andrew AS, Clifford GM, Lazarus P, Grankvist K, Johansson M, Arnold SM, Melander O, Brunnström H, Boccia S, Cadoni G, Timens W, Obeidat M, Xiangjun Xiao X, Houlston RS, Hung RJ, Brennan P. Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers. PLOS Genetics. 2021; Mar 5;17(3):e1009254. doi: 10.1371/journal.pgen.1009254. Online ahead of print. PMID: 33667223.

Xu T, Cheng D, Zhao Y, Zhang J, Zhu X, Zhang F, Chen G, Wang Y, Yan X, Robertson GP, Gaddameedhi S, Lazarus P, Wang S, Zhu J. Variable tandem repeats function as a polymorphic enhancer of human telomerase reverse transcriptase gene. Proc Natl Acad Sci. (accepted upon revision).

Grants

Active

1R01 ES025460-01A1 (Lazarus, P)
2015-2021
NIH/NIEHS
Title: The UGT2A and 3A metabolizing enzymes and tobacco-related cancer risk
The goal of this proposal is to examine the role of two previously under-studied phase II metabolizing enzyme sub-families (UGT2A and UGT3A) on drug response and cancer risk.

Faculty Pilot Grant on Drug & Alcohol Abuse, WSU (Lazarus, P)
2019-2021
Title: The overlapping metabolism of opioids and cannabis: Potential consequences for toxicity and withdrawal among opioids users.
The goal of this study is to examine the metabolic pathways involved in the metabolism of major cannabis constituents and their metabolites, and to explore potential drug-drug interactions between cannabis compounds and major opioids including hydrocodone and morphine.

Washington Research Foundation (Co-PI: Lazarus, P, Prasad B)
2021-2022
Title: Precision tools for drug metabolizing enzyme research and drug development
The goal of this study is to develop tools for metabolism and proteomic studies.

Completed (selected)

1 RO1 CA59917 (Lazarus, P)
1995–2008
NIH/NCI
Title: Analysis of 5’ UTR-mediated regulation of p53 expression.
The major goal of this project was to better understand the mechanisms underlying this novel regulatory pathway for the p53 tumor suppressor protein and to elucidate whether this regulation can serve as a biomarker cancer development and progression.

1 RO1 DE12206 (Lazarus, P)
1997-2002
NIH/NCI
Title: Molecular markers of oral cancer risk.
The major goal of this project was to elucidate highly susceptible genotypic and phenotypic profiles for xenobiotic-metabolizing enzymes as determinants of oral cancer risk for different racial groups.

PO1-CA68384 (Lazarus, P)
2001-2008
NIH/NCI
Title: Tobacco and cancer risk: Dose, metabolism and genetics
The major goal of this program project was the examination of epidemiologic and molecular factors involved in risk for tobacco-related cancers. In addition to being the PI, Dr. Lazarus was a project leader for one of the three independent projects within this proposal and a co-investigator on a second project led by J.P. Richie.

R01 DE013158-13 (Lazarus, P)
2001-2013
NIH/NIDCR
“UDP-Glucuronosyltransferase Genotype and Cancer Risk”
The major goals of this application had been to examine the role of UGT family of enzymes in genetic susceptibility to cancer.

1R01 CA164366-01A1 (Lazarus, P)
2012-2018
NIH/NCI
“Role of Pharmacogenetics on Exemestane Metabolism and Toxicity”
This was a collaborative study with Queens Unversity (Kingston, ON), Penn State University (Hershey, PA) and Harvard University (Boston, MA) to fully characterize the metabolism of the aromatase inhibitor, exemestane (commonly used for the treatment and prevention of breast cancer), and to explore the effects, both in vitro and in vivo, of polymorphisms that occur in enzymes that mediate exemestane metabolic reactions.

Lazarus Lab Student and Postdoc Grants

1R01 ES025460-01Suppl (A Vergara)
2016-2018
NIH/NIEHS
Title: The UGT2A and 3A metabolizing enzymes and tobacco-related cancer risk.

Fellowship for Doctorate Studies, Mexico (Perez-Paramo Y)
2018-2020
Comisión Nacional de Ciencia y Tecnología (CONACyT)

Fulbright García-Robles Fellowship (Perez-Paramo Y)
2015 – 2018
Fulbright Program, US-Mexico

Pfizer Fellowship (Dluzen D)
2010-2011
Title: Examination of miRNA regulation of UGT enzymes.

7-08-CST-01, (Erickson K)
2008-2011
American Diabetes Association Fellowship
Title: The Effects of UDP-Glucuronosyltansferase Polymorphisms on Olanzapine Metabolism: Implications for Obesity and Diabetes Risk.

K099 (Gallagher, C)
2008-2010
NIH/NCI
Title: Role of gender in risk for tobacco-related cancers.
Dr. Lazarus served as the primary mentor for Dr. Gallagher during the 2-year mentorship phase of this proposal.