Postdoctoral training in development and genetics, Howard Hughes Medical Institute, University of California at San Francisco
Ph.D. in biochemistry, Dartmouth Medical School, Hanover, N.H.
Bachelor of Science in electrophysiology and biophysics, Beijing University, Beijing, China
Courses taught or currently teaching:
Doctor of Pharmacy
PharDSci 515 Immunology (2014)
PharDSci 542 Integrated Pharmacology (Immunology, Infectious Diseases, Cancer) (Instructor of Record, 2015-present)
Ph.D. in Pharmaceutical Sciences
PharmSci 560 Methods in Molecular and Cellular Biology (Instructor of Record, 2015-present)
Title: Beta-secretase enzyme compositions and methods
Assignee: Elan Pharmaceuticals, Inc. (2000) U. S. Patent No. 6,627,739
Inventors: John Anderson, Guriqbal Basi, Minh Tam Doan, Normand Frigon, John Varghese, Michael Power, Sukanto Power, Gwen Tatsuno, Jay Tung, Shuwen Wang, Lisa McConlogue.
Stem Cell Biology
Autoimmune disorders are chronic diseases that adversely affect the quality of life of up to 10% of the population and are one of the top ten leading causes of death. Females acquire autoimmune disorders at a rate that is 3-9 times higher than males. Each autoimmune disorder is unique, but they all are caused by a breakdown of tolerance against self-antigens, leading to inflammatory immune responses that promote organ/tissue damage. Although autoantigen-specific T and B cells as well as regulatory T cells have been suggested to play key roles in the progression of the disease-specific pathology, the exact mechanism of autoimmunity is not known. Previous studies, including ours, have found that telomerase is important for the function of various immune cells (e.g. T cells and HSCs). One of the main projects my research program focuses on is to study the function of telomerase in relationship with various immune cells, especially subsets of T cells, in the context of autoimmunity using several mouse models.
Recent Research Support
07/12 – 06/13 | R01 AI102543 (Co-PI), T-cell immunity to polyomavirus infection
08/04 – 08/14 | R01 GM071725 (Co-PI), Repression of the hTERT gene during cell differentiation
Cheng, D., Wang, S., Jia, W., Zhao, Y., Zhang, F., Kang, J., and J. Zhu. (2017) Regulation of human and mouse telomerase genes by genomic contexts and transcription factors during embryonic stem cell differentiation. Scientific Reports 7(1):16444 (DOI:10.1038/s41598-017-16764-w)
Ma, Y., Wang, S., Zhao, Y., Hao, S., Spector, DJ., Lim, B., Zheng, S., El-Deiry, WS., and Zhu, J. (2015) A combinatory strategy for circulating tumor cell detection using microfilter capturing and adenoviral imaging. Molecular Cancer Therapeutics 14, 835-43
Jia, W., Wang, S., Horner, J. W., Wang, N., Wang, H., Gunther, E. J., DePinho, R. A., and Zhu, J. (2011) A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. FASEB J. 25, 979-989. (Co-first author)
Wang, S., Hu, C., and J. Zhu. (2010) Distinct and temporal roles of nucleosomal remodeling and histone deacetylation in the repression of the hTERT gene. Mol. Biol. Cell. 21, 821–832.
Wang, S., Zhao, Y., Leiby, M., and J. Zhu. (2009) A new positive/negative selection scheme for precise BAC recombineering. Mol Biotechnol. 42, 110-116.
Wang, S., Hu, C., and J. Zhu. (2007) Transcriptional silencing of a novel hTERT reporter locus during in vitro differentiation of mouse embryonic stem cells. Mol. Biol. Cell. 18, 669–677.