The Department of Pharmaceutical Sciences

 

Meet the Chair

Gary M. Pollack, Ph.D. Philip Lazarus, Ph.D.

Chair of this department is Dr. Philip Lazarus, who is focused on the regulation of metabolic pathways, carcinogenesis, gene-environment interactions, and pharmacogenetics. Lazarus has taken a targeted pathway approach to establish how environmental or drug exposures interact with genetic variation to alter disease risk or patient response to drugs.

His research has spanned the spectrum of cancer causation, prevention and treatment, focusing on:

  1. tobacco carcinogen metabolism and cancer susceptibility,
  2. nicotine metabolism and pharmacogenetics,
  3. pharmacogenetics of chemotherapeutic agents, particularly focusing on agents used for the prevention and treatment of breast cancer, and
  4. epigenetic regulation of metabolic pathways, focusing primarily on the UDP glucuronosyltransferase family of phase II enzymes.

See Dr. Lazarus's faculty bio page for more details.

About the Department

The Department of Pharmaceutical Sciences at WSU Spokane is dedicated to advancing pharmaceutical science through research and education.

Research areas in the Department of Pharmaceutical Sciences include:

  • genetics and genomics
  • epigenetics
  • drug development and novel targets
  • drug delivery mechanisms including viral vectors and nanotechnology

Research themes include:

  • studies of cancer
  • cell signaling
  • drug metabolism
  • rheumatoid arthritis and inflammation
  • tobacco biomarkers and cessation
  • immunology and immunotherapy
  • aging

Faculty and their research

See individual investigator’s faculty bio pages (click on names below) for more details.

Ayesha Ahmed, clinical assistant professor. Research expertise in toxicology for preclinical drug development, metal-induced oxidative stress and tissue injury.

Salah Ahmed, associate professor. Research expertise in rheumatoid arthritis and vascular inflammation.

Gang Chen, associate research professor and director of the mass spec core. Research expertise in tobacco carcinogen metabolism and cancer susceptibility.

De Cheng, assistant research professor. Research expertise in regulatory mechanism of human TERT gene during ESCs differentiation.

Zhaokang Cheng, assistant professor. Research expertise in cardiovascular disease, cell death and signal transduction.

John Clarke, assistant professor. Research expertise in toxicology, drug disposition (emphasis on transporters), and liver disease.

Sayed Daoud, associate professor and director of the pharmsci ph.d. program. Research expertise in cancer genomics, cancer proteomics and bioinformatics.

Travis Denton, clinical assistant professor. Research expertise in synthetic medicinal chemistry, neuroscience, drug metabolism and disposition and pharmacokinetics.

Shobhan Gaddameedhi, assistant professor. Research expertise in gene-environment interaction, genotoxic stress, circadian disruption, environmental carcinogenesis and chronopharmacology of anticancer drugs.

Philip Lazarus, professor and chair. Research expertise in pharmacogenetics, carcinogen metabolism, and breast and tobacco related cancer.

David Liu, associate professor. Research expertise in signaling mechanisms-proliferation and survival of cancer cells.

Kay Meier, professor and associate dean for graduate education. Research expertise in signal transduction, phospholipid metabolism, protein phosphorylation, G protein coupled receptors, and cancer biology.

Senthil Natesan, assistant professor. Research expertise in computational drug design with major focus on membrane permeability, metabolism, and transport of drugs.

Jeannie Padowski, clinical assistant professor. Research expertise in pharmacokinetic and pharmacodynamic modeling, nasal drug delivery for CNS-targeted therapeutics, and neurodegenerative disorders.

Mary Paine, associate professor. Research expertise in drug metabolism and transport, pharmacokinetic modeling and simulation, drug-drug interactions, and natural product-drug interactions.

Connie Remsberg, clinical assistant professor and compounding lab instructor. Research expertise in membrane drug transporters – drug-drug interactions.

Pramod Srivastava, assistant research professor. Research expertise in drug metabolism, drug discovery and pre-clinical drug development.

Grant Trobridge, associate professor. Research expertise in gene therapy, cancer gene discovery and vector mediated oncogenicity/genotoxicity.

Shuwen Wang, clinical associate professor and director of the genomics core. Research expertise in protein biochemistry, molecular biology, fly genetics, developmental biology, stem cell biology, mouse genetics, and viral immunology.

Zhenjia Wang, assistant professor. Research expertise in therapeutic nanoparticles and biological systems “in vivo”, inflammatory diseases and molecular mechanisms.

Boyang (Jason) Wu, assistant professor. Research expertise in cancer biology, signal transduction, anticancer drug development and neuropharmacology.

Zuping Xia, associate research professor and director of the NMR core. Research expertise in drug metabolism and synthesis.

Hui Zhang, associate research professor. Research expertise in tumor biology, tumor Immunology and tumor immunotherapy.

Jiyue Zhu, professor. Research expertise in molecular biology of cancer and aging, epigenetic gene regulation and stem cell biology.

United States Transuranium & Uranium Registries (USTUR) Faculty

Sergey Y. Tolmachev, associate research professor and director. Research expertise in actinide radiochemistry and analysis, radiation protection, internal dosimetry, and biokinetic modeling.

Affiliate Faculty

Weihang Chai, associate professor, WSU College of Medical Sciences. Research expertise in genome stability and telomere maintenance in carcinogenesis and aging.

Min Du, Professor, WSU Department of Animal Sciences. Research expertise in nutraceutical compounds, epigenetic regulation and stem cell differentiation.

Weimin Li, assistant professor, WSU College of Medical Sciences. Research expertise in nuclear signaling regulation of cancer cell growth and modeling of tumor progression.

Adjunct Faculty

Darrell Fisher, research professor in Richland, Washington. Research expertise in nuclear medicine, radiation dosimetry, radiobiology, and design and testing of therapeutic radiopharmaceuticals.

Stephen Warren, assistant professor of chemistry, Gonzaga University in Spokane, Washington. Research expertise in positron emission tomography diagnostic agents, drug lead discovery including virtual screening for drug leads, discovery of new antibiotics, and synthetic medicinal chemistry.

Education

The Department of Pharmaceutical Sciences is also committed to educating the next generation of researchers through the pharmaceutical sciences graduate program. Students are prepared for careers in academia and science and healthcare research through rigorous coursework and extensive laboratory experience. Students work alongside faculty mentors within established laboratories of specialized and focused research.

See Graduate Programs for more details.

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Office staff

Kathleen McDonnell, Office Assistant Kathleen McDonnell
Secretary Supervisor

Kathleen.mcdonnell@wsu.edu
509-368-6573
Office: PBS 429



Pharmaceutical Sciences
emeritus faculty

Gary Meadows
meadows@wsu.edu